By Andrew Franklin
During the process the immune reaction, antigen-activated B cells produce antibodies with elevated affinity for the antigen, a strategy known as affinity maturation. a number produces antibodies with successively better affinities with repeated publicity to an identical antigen, that's the main wherein such a lot vaccines work.
Affinity maturation is determined by hypermutation, an iterative strategy of mutation at antibody-encoding genes, by way of confident collection of B cells expressing antibodies with elevated affinity. The mechanism of hypermutation is taken into account to be one of many final nice mysteries in molecular biology. Mutation may end up in genomic instability, so how are mutations selectively brought to antibody-encoding genes in activated B cells?
A significant step forward got here in 2000 with the invention that activation-induced deaminase (AID) is admittedly required for hypermutation. This used to be in 2002 via proof that reduction without delay edits the DNA that encodes an antibody in an activated B phone. a lot has on the grounds that been learnt in regards to the biochemistry and rules of reduction, however the mechanism in which it truly is recruited in particular to antibody-encoding genes is still enigmatic. figuring out this recruitment is clinically major simply because off-target relief task at oncogenes may end up in chromosomal translocations and tumorigenesis.
This e-book summarizes the study on relief within the context of its vital position within the affinity maturation of B cells.
Read or Download Activation-Induced Deaminase: On the Targeting Mechanism of AID to the Immunoglobulin Loci PDF
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Activation-Induced Deaminase: On the Targeting Mechanism of AID to the Immunoglobulin Loci by Andrew Franklin